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Article

The Devil in the Details: The Emerging Role of Anticitrulline Autoimmunity in Rheumatoid Arthritis

1 Nov 2005

Abstract excerpt

Rheumatoid arthritis is a chronic inflammatory autoimmune disease of unknown cause. The immune response against citrullinated Ags has recently become the prime suspect for disease pathogenesis. Immunity against citrullinated Ags is thought to play a pivotal role in the disease for several reasons: 1) citrullinated Ags are expressed in the target organ, the inflamed joint; 2) anti-citrullinated protein Abs are...

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PMID: 16237041
DOI: 10.4049/jimmunol.175.9.5575

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Source receipt: pubmed, retrieved 7 Sept 2026.

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