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Article

New genes, new dilemmas: FTLD genetics and its implications for families.

American journal of Alzheimer's disease and other dementias - 1 Jan 2000

Goldman Jill S, Adamson Jennifer, Karydas Anna, Miller Bruce L, Hutton Mike

Abstract excerpt

After Alzheimer's disease, frontotemporal lobar degeneration (FTLD) is the second leading cause of dementia in persons less than 65 years of age. Up to 40% of FTLD cases have a positive family history. Research on these families has led to the discovery of four disease-causing genes: microtubule-associated protein tau (MAPT), progranulin (PGRN), valosin-containing protein (VCP), and charged multivesicular body...

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Source

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Identifiers

PMID: 18166610
DOI: 10.1177/1533317507306662
PMCID: PMC10846215

Genes

MAPT
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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