Article
Recent advances in the molecular genetics of frontotemporal lobar degeneration.
Functional neurology - 1 Jan 2000
Rainero Innocenzo, Rubino E, Michelerio A, D'Agata F, Gentile Salvatore, Pinessi Lorenzo
Abstract excerpt
The term frontotemporal lobar degeneration (FTLD) describes a spectrum of neurodegenerative disorders associated with deposition of misfolded proteins in the frontal and temporal lobes. Up to 40% of FTLD patients reports a family history of neurodegeneration, and approximately 1/3 of familial cases shows an autosomal dominant pattern of inheritance of the phenotype. Over the past two decades, several causative...
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