Article
The heritability and genetics of frontotemporal lobar degeneration.
Neurology - 3 Nov 2009
Rohrer J D, Guerreiro R, Vandrovcova J, Uphill J, Reiman D, Beck J, Isaacs A M, Authier A, Ferrari R, Fox N C, Mackenzie I R A, Warren J D, de Silva R, Holton J, Revesz T, Hardy J, Mead S, Rossor M N
Abstract excerpt
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a genetically and pathologically heterogeneous neurodegenerative disorder. METHODS: We collected blood samples from a cohort of 225 patients with a diagnosis within the FTLD spectrum and examined the heritability of FTLD by giving each patient a family history score, from 1 (a clear autosomal dominant history of FTLD) through to 4 (no family history of...
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