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Article

The genetics and neuropathology of frontotemporal lobar degeneration.

Acta neuropathologica - 1 Sept 2012

Sieben Anne, Van Langenhove Tim, Engelborghs Sebastiaan, Martin Jean-Jacques, Boon Paul, Cras Patrick, De Deyn Peter-Paul, Santens Patrick, Van Broeckhoven Christine, Cruts Marc

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders characterized by disturbances of behavior and personality and different types of language impairment with or without concomitant features of motor neuron disease or parkinsonism. FTLD is characterized by atrophy of the frontal and anterior temporal brain lobes. Detailed neuropathological studies have elicited proteinopathies defined by...

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Identifiers

PMID: 22890575
DOI: 10.1007/s00401-012-1029-x
PMCID: PMC3422616

Genes

GRN
MAPT
VCP

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