Article
Frontotemporal dementia: genetics and genetic counseling dilemmas.
The neurologist - 1 Sept 2004
Goldman Jill S, Farmer Jennifer M, Van Deerlin Vivianna M, Wilhelmsen Kirk C, Miller Bruce L, Grossman Murray
Abstract excerpt
BACKGROUND: Frontotemporal dementia (FTD) is a neurodegenerative disease with early symptoms of personality change and/or language disorder. Approximately 40% of individuals with FTD have a family history of dementia; however, in our experience, less than 10% have clear autosomal dominant inheritance. Mutations in the microtubule-associated protein tau (MAPT) gene have been reported in up to 50% of hereditary...
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