Article
Replication of linkage with bipolar disorder on chromosome 16p in the Eastern Quebec population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008
Mérette Chantal, Roy Marc-André, Bureau Alexandre, Fournier Alain, Emond Claudia, Cliche Denis, Jomphe Valérie, Chagnon Yvon C, Maziade Michel
Abstract excerpt
In a previous study [Maziade et al. (2005); Mol Psychiatry 10:486-499], we provided evidence for linkage (parametric lod score of 4.05) on chromosome 16p for bipolar affective disorder (BP) in 21 kindreds from Eastern Quebec, a population characterized by a founder effect. Using a stringent design, we performed a replication study in a second sample of 27 kindreds (sample 2) collected from the same population and...
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