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Article

Fc gamma RIIa (CD32) polymorphism and onchocercal skin disease: implications for the development of severe reactive onchodermatitis (ROD).

The American journal of tropical medicine and hygiene - 1 Dec 2007

Ali Magdi M M, Elghazali Gehad, Montgomery Scott M, Farouk Salah E, Nasr Amre, Noori Suzan I A, Shamad Mahdi M, Fadlelseed Omar E, Berzins Klavs

Abstract excerpt

The pathologic manifestations of Onchocerca volvulus infection depend on the interplay between the host and the parasite. A genetic single nucleotide polymorphism in the Fc gamma RIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis. This study investigated the relationship between...

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PMID: 18165525

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