Article
Genome-wide search for genes affecting the risk for alcohol dependence.
American journal of medical genetics - 8 May 1998
Reich T, Edenberg H J, Goate A, Williams J T, Rice J P, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit M A, Bucholz K, Porjesz B, Li T K, Conneally P M, Nurnberger J I, Tischfield J A, Crowe R R, Cloninger C R, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H
Abstract excerpt
Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six-center collaborative study to identify...
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