Article
Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice
13 Jul 2010
Abstract excerpt
Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection. Such a vaccine should elicit long-lasting immune responses against conserved determinants in the parasite population. Most blood-stage vaccines, however, induce protective antibodies against surface antigens, which tend to be polymorphic....
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