Article
Template switching: from replication fork repair to genome rearrangements.
Cell - 28 Dec 2007
Branzei Dana, Foiani Marco
Abstract excerpt
Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.
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