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Article

Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.

PloS one - 1 Jan 2012

Trobridge Grant D, Beard Brian C, Wu Robert A, Ironside Christina, Malik Punam, Kiem Hans-Peter

Abstract excerpt

BACKGROUND: Hematopoietic stem cell (HSC) gene therapy has cured immunodeficiencies including X-linked severe combined immunodeficiency (SCID-X1) and adenine deaminase deficiency (ADA). For these immunodeficiencies corrected cells have a selective advantage in vivo, and low numbers of gene-modifi...

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Share to Acute Disease
Share to Anemia, Hemolytic, Congenital Nonspherocytic
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23028826
DOI: 10.1371/journal.pone.0045173
PMCID: PMC3441638

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23028826-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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