Article
Anti-gene padlocks eliminate Escherichia coli based on their genotype.
The Journal of antimicrobial chemotherapy - 1 Feb 2008
Shi Chanjuan, Parker Antony R, Hua Li, Morrell Craig N, Lee Soo Chin, Bandaru Viswanath, Dumler J Stephen, Wu T C, Eshleman James R
Abstract excerpt
OBJECTIVES: Several therapeutic strategies that target nucleic acids exist; however, most approaches target messenger RNA, rather than genomic DNA. We describe a novel oligonucleotide-based strategy, called anti-gene padlocks (AGPs), which eliminate Escherichia coli based on their genotype. METHODS: The strategy employs an oligonucleotide with a double hairpin structure where both strands of the AGP are...
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