Article
Phenotypic conversion of drug-resistant bacteria to drug sensitivity.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 1997
Guerrier-Takada C, Salavati R, Altman S
Abstract excerpt
Plasmids that contain synthetic genes coding for small oligoribonucleotides called external guide sequences (EGSs) have been introduced into strains of Escherichia coli harboring antibiotic resistance genes. The EGSs direct RNase P to cleave the mRNAs transcribed from these genes thereby converting the phenotype of drug-resistant cells to drug sensitivity. Increasing the EGS-to-target mRNA ratio by changing gene...
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