Article
Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension.
The American journal of pathology - 1 Jan 2008
Lawrie Allan, Waterman Elizabeth, Southwood Mark, Evans David, Suntharalingam Jay, Francis Sheila, Crossman David, Croucher Peter, Morrell Nicholas, Newman Christopher
Abstract excerpt
Pulmonary artery smooth muscle cell (PA-SMC) migration and proliferation are key processes in the pathogenesis of pulmonary arterial hypertension (PAH). Recent information suggests that abnormalities in the bone morphogenetic protein (BMP) receptor 2 (BMP-R2) signaling pathway are important in PA...
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