Article
The effects of continuous exposure to epidermal growth factor on the spontaneous transformation of cultured rat liver epithelial cells.
The American journal of pathology - 1 Jan 1992
Tsao M S, Zhang X Y
Abstract excerpt
A long-term continuous exposure to epidermal growth factor (EGF) enhanced the tumorigenicity of spontaneously transformed cells arising in a clonal population of normal cultured rat liver epithelial cells propagated in a selective growth condition. Lengthy EGF exposure also induced the expression...
Topics
- Animals
- Blotting, Northern
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cells, Cultured
- Epidermal Growth Factor
- Epithelial Cells
- Epithelium
- ErbB Receptors
- Gene Expression Regulation, Neoplastic
- Liver
- Liver Neoplasms
- Neoplasm Metastasis
- Phenotype
- Proto-Oncogene Proteins c-myc
- Proto-Oncogene Proteins p21(ras)
- RNA, Messenger
- Rats