Article
Retinoic acid causes abnormal development and segmental patterning of the anterior hindbrain in Xenopus embryos.
Development (Cambridge, England) - 1 Dec 1991
Papalopulu N, Clarke J D, Bradley L, Wilkinson D, Krumlauf R, Holder N
Abstract excerpt
Retinoic acid is a very potent teratogen and has also been implicated as an endogenous developmental signalling molecule in vertebrate embryos. One of the regions of the embryo reliably affected by exogenously applied RA is the hindbrain. In this paper, we describe in detail the hindbrain of Xeno...
Topics
- Animals
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian
- Gastrula
- Gene Expression
- Genes
- Microscopy, Fluorescence
- Morphogenesis
- Phenotype
- Rhombencephalon
- Tretinoin
- Xenopus