Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells.

Abstract excerpt

This study investigates the migration patterns of cranial neural crest cells in retinoic acid (RA)-treated rat embryos using DiI labeling. Wistar-Imamichi rat embryos were treated at the early (9.0 days post coitum, d.p.c.) and late (9.5 d.p.c.) neural plate stages with all-trans RA (2 x 10(-7) M) for 6 hours and further cultured in an RA-free medium. RA exposure stage dependently induced two typical craniofacial...

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