Article
Exogenous retinoic acid causes specific alterations in the development of the midbrain and hindbrain of the zebrafish embryo including positional respecification of the Mauthner neuron.
Mechanisms of development - 1 Mar 1995
Hill J, Clarke J D, Vargesson N, Jowett T, Holder N
Abstract excerpt
Exogenously applied retinoic acid given at the early stages of gastrulation causes abnormal development of the caudal midbrain and anterior hindbrain in vertebrate embryos. We describe the limits of the brain regions that are affected using neuroanatomical criteria in the zebrafish embryo. Analysis of the reticulospinal complex shows that the Mauthner cell, which normally differentiates in rhombomere 4, is...
Topics
- Animals
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Genes, Regulator
- Mesencephalon
- Neurons
- Phenotype
- Prosencephalon
- Reticular Formation
- Rhombencephalon