Article
Genome-wide genetic study in autoimmune disease-prone mice.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014
Obata Masaomi, Ohtsuji Mareki, Iida Yukiyasu, Shirai Toshikazu, Hirose Sachiko, Nishimura Hioroyuki
Abstract excerpt
Mouse models of autoimmune diseases provide invaluable insights into the cellular and molecular bases of autoimmunity. Genetic linkage studies focusing on their abnormal quantitative phenotypes in relation to the loss of self-tolerance will lead to the identification of polymorphic genes that play pivotal roles in the genetic predisposition to autoimmunity. In this chapter, we first overview the basic concepts in...
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