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Article

Evidence for Microtubule Target Engagement in Tumors of Patients Receiving Ixabepilone

15 Dec 2007

Abstract excerpt

PURPOSE: Microtubule-stabilizing agents, such as taxanes, have been shown to be effective anticancer drugs. alpha-Tubulin, a basic unit of microtubules, can undergo several posttranslational modifications after assembly into stabilized microtubules, including acetylation and detyrosination. These modifications have been observed in cell cultures after exposure to microtubule stabilizers. Our objective was to...

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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18094432
DOI: 10.1158/1078-0432.ccr-06-2883

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