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Article

Evaluation of +49 A>G (rs231775) Variant in CTLA4 Gene and SCTLA-4 Serum Levels in Plaque Psoriasis in a Mestizo Mexican Population.

International journal of molecular sciences - 1 Apr 2026

Cortés-Ruiz María Guadalupe, Wheber-Hidalgo Katia Alejandra, Hernández-Nicols Brenda Fernanda, Buenrostro-Camacho Fernando Gabriel, Hernández-Bello Jorge, Graciano-Machuca Omar, Alvarado-Navarro Anabell

Abstract excerpt

Plaque psoriasis (PP) is a chronic immune-mediated skin disorder characterized by T-cell dysregulation and an imbalance between regulatory T cells (Treg) and T helper 17 (Th17) cells. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), a key inhibitory checkpoint molecule expressed on Treg cells, and its soluble isoform (sCTLA-4) are critical regulators of peripheral immune tolerance and may contribute to PP...

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Identifiers

PMID: 41977385
DOI: 10.3390/ijms27073202
PMCID: PMC13073593

Genes

CS
CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Evaluation of +49 A>G (rs231775) Variant in CTLA4 Gene and SCTLA-4 Serum Levels in Plaque Psoriasis in a Mestizo Mexican Population.PMID 41977385Read ↗

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