Article
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome.
Development (Cambridge, England) - 12 Mar 2021
Toussaint Nicolas, Redhead Yushi, Vidal-García Marta, Lo Vercio Lucas, Liu Wei, Fisher Elizabeth M C, Hallgrímsson Benedikt, Tybulewicz Victor L J, Schnabel Julia A, Green Jeremy B A
Abstract excerpt
Characterising phenotypes often requires quantification of anatomical shape. Quantitative shape comparison (morphometrics) traditionally uses manually located landmarks and is limited by landmark number and operator accuracy. Here, we apply a landmark-free method to characterise the craniofacial skeletal phenotype of the Dp1Tyb mouse model of Down syndrome and a population of the Diversity Outbred (DO) mouse...
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