Article
Detection of epidermal growth factor receptor mutation in non-small-cell lung carcinoma using cytological and histological specimens.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000
Xu Haimiao, Sun Wenyong, Zhang Gu, Cheng Yue
Abstract excerpt
PURPOSE: Epidermal growth factor receptor (EGFR) mutations are prerequisites for the targeted therapy with anti-EGFR tyrosine kinase inhibitors (TKIs) in non-small-cell lung carcinomas (NSCLCs). In patients with advanced-stage NSCLC, sometimes cytological specimens, including those from fine-needle aspiration cytology (FNAC) and pleural effusion, are the only materials for mutation analysis. The purpose of this...
Topics
- Adult
- Biomarkers, Tumor
- Biopsy, Fine-Needle
- Carcinoma, Non-Small-Cell Lung
- DNA Mutational Analysis
- ErbB Receptors
- Exons
- Female
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Paraffin Embedding
- Pleural Effusion, Malignant
- Polymerase Chain Reaction
- Predictive Value of Tests