Article
Relative replication capacity and selective advantage profiles of protease inhibitor-resistant hepatitis C virus (HCV) NS3 protease mutants in the HCV genotype 1b replicon system.
Antimicrobial agents and chemotherapy - 1 Mar 2008
He Yupeng, King Martin S, Kempf Dale J, Lu Liangjun, Lim Hock Ben, Krishnan Preethi, Kati Warren, Middleton Timothy, Molla Akhteruzzaman
Abstract excerpt
We characterized the selective advantage profiles of a panel of hepatitis C virus (HCV) NS3 protease mutants with three HCV protease inhibitors (PIs), BILN-2061, ITMN-191, and VX-950, using a genotype 1b HCV replicon system. Selective advantage curves were generated by a novel mathematical method that factors in the degree of drug susceptibility provided by the mutation, the base-level replication capacity of the...
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