Article
The association between polymorphisms in RLIP76 and drug response in epilepsy.
Pharmacogenomics - 1 Dec 2007
Leschziner Guy D, Jorgensen Andrea L, Andrew Toby, Williamson Paula R, Marson Anthony G, Coffey Alison J, Middleditch Claire, Balding David J, Rogers Jane, Bentley David R, Chadwick David, Johnson Michael R, Pirmohamed Munir
Abstract excerpt
INTRODUCTION: Approximately 30% of patients with epilepsy are resistant to treatment with anti-epileptic drugs (AEDs). The ABC drug transporter proteins are hypothesized to mediate drug resistance in epilepsy. More recently, a non-ABC putative transporter, RLIP76, has also been proposed to be involved in the mechanism of pharmacoresistance. One previous association study of six polymorphisms in RLIP76 failed to...
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