Article
Genome-wide association meta-analyses of drug-resistant epilepsy.
EBioMedicine - 1 May 2025
Leu Costin, Avbersek Andreja, Stevelink Remi, Custodio Helena Martins, Chen Siwei, Speed Doug, Bennett Caitlin A, Jonsson Lina, Unnsteinsdóttir Unnur, Jorgensen Andrea L, Cavalleri Gianpiero L, Delanty Norman, Craig John J, Depondt Chantal, Johnson Michael R, Koeleman Bobby P C, Hassanin Emadeldin, Omidvar Maryam Erfanian, Krause Roland, Lerche Holger, Marson Anthony G, O'Brien Terence J, Sander Josemir W, Sills Graeme J, Striano Pasquale, Zara Federico, Stefansson Hreinn, Stefansson Kari, May Patrick, Neale Benjamin M, Lal Dennis, Berkovic Samuel F, Sisodiya Sanjay M
Abstract excerpt
BACKGROUND: Epilepsy is one of the most common neurological disorders, affecting over 50 million people worldwide. One-third of people with epilepsy do not respond to currently available anti-seizure medications, constituting one of the most important problems in epilepsy. Little is known about the molecular pathology of drug resistance in epilepsy, in particular, possible underlying genetic factors are largely...
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