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Disruption of the Pf<i>PK7</i>Gene Impairs Schizogony and Sporogony in the Human Malaria Parasite<i>Plasmodium falciparum</i>

15 Dec 2007

Abstract excerpt

PfPK7 is an orphan protein kinase of Plasmodium falciparum with maximal homology to MEK3/6 and to fungal protein kinase A proteins in its C-terminal and N-terminal regions, respectively. We showed previously that recombinant PfPK7 is active on various substrates but is unable to phosphorylate the Plasmodium falciparum mitogen-activated protein kinase homologues, suggesting that it is not a MEK functional...

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PMID: 18083830
DOI: 10.1128/ec.00245-07

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