Article
No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease.
Neurobiology of aging - 1 Aug 2009
Tractenberg Rochelle E, Aisen Paul S, Hancock Gregory R, Rebeck G William
Abstract excerpt
This study sought to determine if there are detectible influences on the symptoms of Alzheimer's disease (AD) from the genetic risk factor for AD, the epsilon4 allele of apolipoprotein-E (APOE). Using data from two cohorts of AD patients, a cross-sectional latent variable model of AD was tested with three symptom factors explaining variability in the observed variables after taking a general neurological factor...
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