Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.

Biological psychiatry - 1 May 2008

Fullerton Janice M, Willis-Owen Saffron A G, Yalcin Binnaz, Shifman Sagiv, Copley Richard R, Miller Susette R, Bhomra Amarjit, Davidson Stuart, Oliver Peter L, Mott Richard, Flint Jonathan

Abstract excerpt

BACKGROUND: Exploiting synteny between mouse and human disease loci has been proposed as a cost-effective method for the identification of human susceptibility genes. Here we explore its utility in an analysis of a human personality trait, neuroticism, which can be modeled in mice by tests of emotionality. We investigated a mouse emotionality locus on chromosome 1 that contains no annotated genes but abuts four...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety Disorders
Share to Arousal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Emotions

Share to Neurotic Disorders

Share to RGS Proteins

Share to Sequence Analysis

Share to Synteny

Source

Identifiers

PMID: 18083140
DOI: 10.1016/j.biopsych.2007.10.019

Genes

RGS18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.PMID 18083140Read ↗

Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.Semantic proximity Read ↗

Gene-based association analysis identified 190 genes with polymorphisms affecting neuroticismSemantic proximity Read ↗

Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.Semantic proximity Read ↗

An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.Semantic proximity Read ↗

Integrating genome-wide association study and expression quantitative trait loci data identifies multiple genes and gene set associated with neuroticism.Semantic proximity Read ↗

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Semantic proximity Read ↗

Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.Semantic proximity Read ↗

Gene-based association analysis identifies 190 genes affecting neuroticism.Semantic proximity Read ↗

Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets.Semantic proximity Read ↗

The genetics of neuroticism: Insights from the Maudsley rat model and human studiesSemantic proximity Read ↗

Spatial and temporal expression patterns of genes around nine neuroticism-associated loci.Semantic proximity Read ↗

The influence of X chromosome variants on trait neuroticismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.