Article
Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development.
Development (Cambridge, England) - 1 Sept 2000
Fay D S, Han M
Abstract excerpt
We have identified strong loss-of-function mutations in the C. elegans cyclin E gene, cye-1. Mutations in cye-1 lead to the underproliferation of many postembryonic blast lineages as well as defects in fertility and gut-cell endoreduplication. In addition, cye-1 is required maternally, but not zygotically for embryonic development. Our analysis of vulval development in cye-1 mutants suggests that a timing...
Topics
- Amino Acid Sequence
- Animals
- Biological Clocks
- Biomarkers
- Caenorhabditis elegans
- Cell Count
- Cell Cycle
- Cell Cycle Proteins
- Cell Differentiation
- Cell Division
- Cell Lineage