Article
Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates.
European journal of haematology - 1 Mar 2008
Gangat Naseema, Strand Jacob, Lasho Terra L, Finke Christy M, Knudson Ryan A, Pardanani Animesh, Li Chin-Yang, Ketterling Rhett P, Tefferi Ayalew
Abstract excerpt
The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a -Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 (n = 4), trisomy 9 (n = 2),...
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