Cytogenetic abnormalities in polycythemia vera: phenotypic correlates and prognostic relevance in 669 informative cases.

doi:10.3324/haematol.2025.287569

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Article

Cytogenetic abnormalities in polycythemia vera: phenotypic correlates and prognostic relevance in 669 informative cases.

Haematologica - 1 Sept 2025

Iftikhar Moazah, Rana Masooma, Jadoon Yamna, Abdelmagid Maymona, Reichard Kaaren, Mendoza Cinthya Zepeda, Pardanani Animesh, Tefferi Ayalew, Gangat Naseema

Abstract excerpt

The main objective of the current study was to provide a detailed account of the prognostic relevance of abnormal karyotype and associated specific cytogenetic abnormalities in polycythemia vera (PV). Six hundred and sixty-nine PV patients were informative, of whom 436 (65%) were evaluated within 1 year of diagnosis. Karyotype abnormalities were found in 67 (15%) patients, including isolated abnormalities of loss...

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Topics

Humans
Polycythemia Vera
Male
Female
Middle Aged
Prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Chromosome Aberrations

Adult

Aged, 80 and over

Phenotype

Mutation

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40145292
DOI: 10.3324/haematol.2025.287569
PMCID: PMC12399929

Genes

SRSF2
IDH2

Provenance

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