Article
Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden.
Leukemia - 1 Sept 2007
Vannucchi A M, Antonioli E, Guglielmelli P, Longo G, Pancrazzi A, Ponziani V, Bogani C, Ferrini P R, Rambaldi A, Guerini V, Bosi A, Barbui T
Abstract excerpt
The aim of this study was to determine whether the burden of JAK2(V617F) allele correlated with major clinical outcomes in patients with polycythemia vera (PV). To this end, we determined JAK2 mutant allele levels in granulocytes of 173 PV patients at diagnosis. The mean (+/-s.d.) mutant allele burden was 52% (+/-29); 32 patients (18%) had greater than 75% mutant allele. The burden of JAK2(V617F) allele...
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