Article
JAK2 V617F allele burden in polycythemia vera: burden of proof.
Blood - 20 Apr 2023
Moliterno Alison R, Kaizer Hannah, Reeves Brandi N
Abstract excerpt
Polycythemia vera (PV) is a hematopoietic stem cell neoplasm defined by activating somatic mutations in the JAK2 gene and characterized clinically by overproduction of red blood cells, platelets, and neutrophils; a significant burden of disease-specific symptoms; high rates of vascular events; and evolution to a myelofibrosis phase or acute leukemia. The JAK2V617F variant allele frequency (VAF) is a key...
Topics
- Humans
- Alleles
- Janus Kinase 2
- Mutation
- Polycythemia Vera
- Primary Myelofibrosis
- Thrombosis