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Article

The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection.

Hepatology (Baltimore, Md.) - 1 Mar 2008

Einav Shirit, Sklan Ella H, Moon Hyang Mi, Gehrig Elizabeth, Liu Ping, Hao Ying, Lowe Anson W, Glenn Jeffrey S

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) is an important cause of chronic liver disease and is complicated by hepatocellular carcinoma (HCC). Mechanisms whereby the virus promotes cellular transformation are poorly understood. We hypothesized that the guanosine triphosphatase activity encoded in the HCV NS4B protein's nucleotide binding motif (NBM) might play a role in the transformation process. Here we report that...

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Identifiers

PMID: 18081150
DOI: 10.1002/hep.22108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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