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Article

Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation.

The Journal of biological chemistry - 12 May 2006

Li Hongxiu, Kobayashi Masayuki, Blonska Marzenna, You Yun, Lin Xin

Abstract excerpt

Stimulation of cells with tumor necrosis factor (TNFalpha) triggers a recruitment of various signaling molecules, such as RIP, to the TNFalpha receptor 1 complex, leading to activation of NF-kappaB. Previous studies indicate that RIP plays an essential role for TNFalpha-induced NF-kappaB activation, but the molecular mechanism by which RIP mediates TNFalpha signals to activate NF-kappaB is not fully defined....

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Source

Identifiers

PMID: 16543241
DOI: 10.1074/jbc.M600620200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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