Article
Cardiac-specific overexpression of the human short CLC-3 chloride channel isoform in mice.
Clinical and experimental pharmacology & physiology - 1 Apr 2009
Xiong Dazhi, Wang Ge-Xin, Burkin Dean J, Yamboliev Ilia A, Singer Cherie A, Rawat Shanti, Scowen Paul, Evans Rebecca, Ye Linda, Hatton William J, Tian Honglin, Keller Phillip S, McCloskey Diana T, Duan Dayue, Hume Joseph R
Abstract excerpt
1. ClC-3 has been proposed as a molecular candidate responsible for volume-sensitive outwardly rectifying anion channels (VSOAC) in cardiac and smooth muscle cells. To further test this hypothesis, we produced a novel line of transgenic mice with cardiac-specific overexpression of the human short ClC-3 isoform (hsClC-3). 2. Northern and western blot analyses demonstrated that mRNA and protein levels of the short...
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