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Article

Trapping the on-pathway folding intermediate of Im7 at equilibrium.

Journal of molecular biology - 30 Jul 2004

Spence Graham R, Capaldi Andrew P, Radford Sheena E

Abstract excerpt

The four-helical protein Im7 folds via a rapidly formed on-pathway intermediate (k(UI)=3000 s(-1) at pH 7.0, 10 degrees C) that contains three (helices I, II and IV) of the four native alpha-helices. The relatively slow (k(IN)=300 s(-1)) conversion of this intermediate into the native structure is driven by the folding and docking of the six residue helix III onto the developing hydrophobic core. Here, we...

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Source

Identifiers

PMID: 15312774
DOI: 10.1016/j.jmb.2004.05.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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