Article
Conformational dynamics is more important than helical propensity for the folding of the all α-helical protein Im7.
Protein science : a publication of the Protein Society - 1 Dec 2013
Figueiredo Angelo Miguel, Whittaker Sara B-M, Knowling Stuart E, Radford Sheena E, Moore Geoffrey R
Abstract excerpt
Im7 folds via an on-pathway intermediate that contains three of the four native α-helices. The missing helix, helix III, is the shortest and its failure to be formed until late in the pathway is related to frustration in the structure. Im7H3M3, a 94-residue variant of the 87-residue Im7 in which helix III is the longest of the four native helices, also folds via an intermediate. To investigate the structural...
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