Article
Modulation of bacterial Type III secretion system by a spermidine transporter dependent signaling pathway.
PloS one - 12 Dec 2007
Zhou Lian, Wang Jing, Zhang Lian-Hui
Abstract excerpt
BACKGROUND: Many gram-negative bacterial pathogens employ Type III secretion systems (T3SS) to inject effector proteins into host cells in infectious processes. METHODOLOGY/PRINCIPAL FINDINGS: By screening a transposon mutant library of P. aeruginosa, we found that mutation of spuDEFGH, which encode a major spermidine uptake system, abolished the expression of the exsCEBA operon that codes for key T3SS regulators...
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