Article
ExsD inhibits expression of the Pseudomonas aeruginosa type III secretion system by disrupting ExsA self-association and DNA binding activity.
Journal of bacteriology - 1 Mar 2010
Brutinel Evan D, Vakulskas Christopher A, Yahr Timothy L
Abstract excerpt
Pseudomonas aeruginosa utilizes a type III secretion system (T3SS) to damage eukaryotic host cells and evade phagocytosis. Transcription of the T3SS regulon is controlled by ExsA, a member of the AraC/XylS family of transcriptional regulators. ExsA-dependent transcription is coupled to type III secretory activity through a cascade of three interacting proteins (ExsC, ExsD, and ExsE). Genetic data suggest that...
Topics
- Bacterial Proteins
- DNA, Bacterial
- Gene Expression Regulation, Bacterial
- Mutation
- Protein Binding
- Pseudomonas aeruginosa
- Recombinant Fusion Proteins
- Repressor Proteins
- Signal Transduction
- Trans-Activators
- Transcription, Genetic