DsbA of Pseudomonas aeruginosa is essential for multiple virulence factors.

doi:10.1128/IAI.71.3.1590-1595.2003

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Article

DsbA of Pseudomonas aeruginosa is essential for multiple virulence factors.

Infection and immunity - 1 Mar 2003

Ha Un-Hwan, Wang Yanping, Jin Shouguang

Abstract excerpt

DsbA is a periplasmic thiol:disulfide oxidoreductase which contributes to the process of protein folding by catalyzing the formation of disulfide bonds. In this study, we demonstrate that the dsbA gene is required for the expression of the type III secretion system under low-calcium inducing conditions, intracellular survival of P. aeruginosa upon infection of HeLa cells, and twitching motility. The diverse...

Topics

HeLa Cells
Humans
Mutation
Protein Disulfide-Isomerases
Pseudomonas aeruginosa
Virulence Factors

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PMID: 12595484
DOI: 10.1128/IAI.71.3.1590-1595.2003
PMCID: PMC148828

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