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Article

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

Nature genetics - 1 Jan 2008

Saal Lao H, Gruvberger-Saal Sofia K, Persson Camilla, Lövgren Kristina, Jumppanen Mervi, Staaf Johan, Jönsson Göran, Pires Maira M, Maurer Matthew, Holm Karolina, Koujak Susan, Subramaniyam Shivakumar, Vallon-Christersson Johan, Olsson Håkan, Su Tao, Memeo Lorenzo, Ludwig Thomas, Ethier Stephen P, Krogh Morten, Szabolcs Matthias, Murty Vundavalli V V S, Isola Jorma, Hibshoosh Hanina, Parsons Ramon, Borg Ake

Abstract excerpt

Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis. Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast cancers that are nearly always of the BBC subtype; however, the precise molecular lesions a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18066063
DOI: 10.1038/ng.2007.39
PMCID: PMC3018354

Genes

BRCA1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18066063-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.PMID 18066063Read ↗

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