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Gross rearrangements in BRCA1 but not BRCA2 play a notable role in predisposition to breast and ovarian cancer in high-risk families of German origin.

Cancer genetics and cytogenetics - 1 Jul 2006

Preisler-Adams Sabine, Schönbuchner Ines, Fiebig Britta, Welling Brigitte, Dworniczak Bernd, Weber Bernhard H F

Abstract excerpt

A total of 226 index cases from high-risk hereditary breast and ovarian cancer families of German origin who had tested negative for small nucleotide alterations in BRCA1 and BRCA2 were analyzed for gross genomic rearrangements at the two gene loci by the multiplex ligation-dependent probe amplification technique. Six large genomic alterations were identified in BRCA1, while no gross rearrangements were found in...

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Source

Identifiers

PMID: 16772120
DOI: 10.1016/j.cancergencyto.2005.07.005

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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