Article
A functional role of Stat3 in in vivo megakaryopoiesis.
Blood - 1 May 2002
Kirito Keita, Osawa Masatake, Morita Haruhiko, Shimizu Ritsuko, Yamamoto Masayuki, Oda Atsushi, Fujita Hiroyoshi, Tanaka Masaru, Nakajima Koichi, Miura Yasusada, Ozawa Keiya, Komatsu Norio
Abstract excerpt
The signal transducer and activator of transcription 3 (Stat3), a member of the Stat family of proteins, is commonly activated by thrombopoietic cytokines including thrombopoietin (TPO), interleukin (IL)-6, and interleukin-11. This finding strongly suggested that Stat3 has an important role in megakaryopoiesis and thrombopoiesis. To clarify the functional role of Stat3 in in vivo megakaryopoiesis and...
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