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Article

Rapid/Sustained Anti-anthrax Passive Immunity Mediated by Co-administration of Ad/AAV

4 Dec 2007

Abstract excerpt

Achieving both immediate and sustained protection against diseases caused by bacterial toxins and extracellular pathogens is a challenge in developing biodefense therapeutics. We hypothesized that a single co-administration of an adenovirus (Ad) vector and an adeno-associated virus (AAV) vector, both expressing a pathogen-specific monoclonal antibody, would provide rapid, persistent passive immunotherapy against...

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PMID: 18059375
DOI: 10.1038/sj.mt.6300344

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