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Article

Effect of CpG Oligonucleotides on Vaccine-Induced B Cell Memory

1 Oct 2008

Abstract excerpt

Adding synthetic oligodeoxynucleotides containing unmethylated CpG motifs to Anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed and magnitude of the resultant Ab response. Ab titers persist in the protective range for >1 year, significantly longer than in animals vaccinated with AVA alone. Unexpectedly, a majority of mice immunized with CpG-adjuvanted AVA maintained resistance to...

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PMID: 18832738
DOI: 10.4049/jimmunol.181.8.5785

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