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Article

Psoriasis is associated with increased beta-defensin genomic copy number.

Nature genetics - 1 Jan 2008

Hollox Edward J, Huffmeier Ulrike, Zeeuwen Patrick L J M, Palla Raquel, Lascorz Jesús, Rodijk-Olthuis Diana, van de Kerkhof Peter C M, Traupe Heiko, de Jongh Gys, den Heijer Martin, Reis André, Armour John A L, Schalkwijk Joost

Abstract excerpt

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin...

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Identifiers

PMID: 18059266
DOI: 10.1038/ng.2007.48
PMCID: PMC2447885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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