Article
In vitro evidence of propagation of superoxide dismutase-1 protein aggregation in canine degenerative myelopathy.
Veterinary journal (London, England : 1997) - 1 Aug 2021
Tanaka N, Kimura S, Kamatari Y O, Nakata K, Kobatake Y, Inden M, Yamato O, Urushitani M, Maeda S, Kamishina H
Abstract excerpt
Canine degenerative myelopathy (DM) is a progressive and fatal neurodegenerative disorder that has been linked to mutations in the superoxide dismutase 1 (SOD1) gene. The accumulation of misfolded protein aggregates in spinal neurons and astrocytes is implicated as an important pathological process in DM; however, the mechanism of protein aggregate formation is largely unknown. In human neurodegenerative...
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